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An end-to-end staining and analysis pipeline to identify immune cell infiltrates in oral cancer by multiplex immunohistochemistryWhitepaperThe ability to probe the tumor microenvironment (TME) at the single cell level is important for understanding of interactions between tumors and immune cells, particularly whether immune cells have infiltrated into tumor nests, and with regards to the presence or absence of immune checkpoint markers. The ability to interrogate these questions relies on the ability to assess multiple biomarkers simultaneously for cell phenotyping in their spatial context. Here we demonstrate rapid design and optimization of a panel of antibodies for multiplexed immunohistochemical staining of a series of oral cancer tumor samples.
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Infographic: Multiplex immunofluorescence techniques explainedInfographicMultiplex immunohistochemistry-immunofluorescence (mIHC/mIF) techniques enable the simultaneous detection of multiple proteins of interest in a single sample. This provides numerous benefits in the examination of different tissues, such as a tumor biopsy. Learn about the benefits of mIHC/mIF experimental approaches and key spatial biology techniques. such as tyramide signal amplification (TSA) and cyclic immunofluorescence.
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IgG Fractions: Enrich Affinity and Reduce BackgroundeBookComparing and contrasting antiserum and IgG fractions can guide scientists searching for the right reagent to meet immunoassay-specific needs.
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Developing Effective Therapeutics for Difficult-to-Treat CancerseBookRecent years have introduced a variety of novel, targeted therapies for both hematopoietic and solid tumors. This includes monoclonal antibody therapies, CAR-T cells, bispecific antibodies, vaccines, and combination immunotherapies based on checkpoint blockade. Despite these therapeutic advances, some cancers remain extremely difficult to treat. In this eBook, we highlight some hard-to-treat cancer types including breast cancer, pancreatic cancer, and cervical cancer, and recent research into the development of therapies to advance treatment of these cancers. This includes biomarker identification in breast cancer and the development of CAR-T cells to treat glioma.
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White Paper: Multiplex Cyclic Immunofluorescence WorkflowWhitepaperMultiplex immunohistochemistry (IHC) technologies are powerful tools to visualize multiple markers in the same tissue sample. These techniques, which include tyramide signal amplification and cyclic immunofluorescence, help scientists understand the cells that make up a tissue, what markers they express, their spatial distribution, and their potential interactions with one another. These methods depend on antibodies that are specific to the target, produce a clean signal, and have low background.
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