Phospho-mTOR (S2448) and Total mTOR ELISA Kit
Product Details
Specifications
- Pre-Coated 96-well Strip Plate, 1 each
- Positive Control vial, 1 each
- anti-Pan Detection Antibody
- anti-Phos Detection Antibody
- Assay Diluent
- HRP-conjugated Secondary Antibody
- TMB Substrate, 12 ml
- Stop Solution, 8 ml
- 20X Wash Buffer, 25 ml
- 2X Lysis Buffer, 5ml
Additional Product Information
Studies of the mammalian target of rapamycin (mTOR) and its homologs demonstrate a role in integrating signals from growth factors, nutrients, stress, and cellular energy levels to control cell growth, translation initiation, ribosome biogenesis, and transcription factor localization. mTOR is the direct target of the cell cycle arresting activity of rapamycin. mTOR interacts with Raptor or Rictor to form the mTORC1 and mTORC2 complexes respectively. The mTORC1 complex also includes mLst8/GbetaL and functions to phosphorylate S6K and 4EBP1. The mTORC2 complex also includes mLst8/GbetaL, mSIN1 and protor-1 and functions to phosphorylate Akt.
Alternate Names
FK506 binding protein 12-rapamycin associated protein 2;FK506-binding protein 12-rapamycin complex-associated protein 1;FKBP12-rapamycin complex-associated protein;FKBP12-rapamycin complex-associated protein 1;FKBP-rapamycin associated protein;FRAP;FRAP1;FRAP2;mammalian target of rapamycin;Mechanistic target of rapamycin;mechanistic target of rapamycin (serine/threonine kinase);mTOR;RAFT1;rapamycin and FKBP12 target 1;rapamycin associated protein FRAP2;rapamycin target protein 1;RAPT1;serine/threonine-protein kinase mTOR;SKS