Phospho-STAT3 (Y705) and Total STAT3 ELISA Kit
Product Details
Specifications
- Pre-Coated 96-well Strip Plate, 1 each
- Positive Control vial, 1 each
- anti-Pan Detection Antibody
- anti-Phos Detection Antibody
- Assay Diluent
- HRP-conjugated Secondary Antibody
- TMB Substrate, 12 ml
- Stop Solution, 8 ml
- 20X Wash Buffer, 25 ml
- 2X Lysis Buffer, 5ml
Additional Product Information
STAT3 (signal transducer and activator of transcription 3) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein [taken from NCBI Entrez Gene (GeneID:6774)].
Alternate Names
acute-phase response factor;ADMIO;ADMIO1;APRF;DNA-binding protein APRF;HIES;signal transducer and activator of transcription 3