/ Antibodies & Antigens / Primary Antibodies / Mouse anti-HER3/ErbB3 Monoclonal Antibody [BLGM095]
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Primary Antibodies  

Mouse anti-HER3/ErbB3 Monoclonal Antibody [BLGM095]

bethyl
Bethyl Laboratories Catalog #
Target:
HER3/ErbB3
Reactivity:
Human
Applications:
IHC
Host:
Mouse
Clonality:
Monoclonal
Clone:
BLGM095
Format:
Whole IgG
Isotype:
IgG2a
Conjugate:
Unconjugated
Purity:
Purified
100 µl

20 µl

$136.00 $516.00
Qty:
Bulk Request

Product Details

Specifications

Reactivity
Human
Antigen Species
Human
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-buffered Saline with 1% BSA and <0.1% Sodium Azide
Request Formulation Change
Country of Origin
USA

Additional Product Information

ErbB3, also known as HER3, is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors[taken from NCBI Entrez Gene (Gene ID: 2065)].

2065
ERBB3
erb-b2 receptor tyrosine kinase 3
P21860
Receptor tyrosine-protein kinase erbB-3

Alternate Names

c-erbB3;c-erbB-3;ErbB-3;erbB3-S;HER3;human epidermal growth factor receptor 3;LCCS2;MDA-BF-1;p180-ErbB3;p45-sErbB3;p85-sErbB3;proto-oncogene-like protein c-ErbB-3;receptor tyrosine-protein kinase erbB-3;tyrosine kinase-type cell surface receptor HER3;v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3