Rabbit anti-FOXM1 Recombinant Monoclonal Antibody [BLR365N]
Product Details
Specifications
Immunogen was a peptide representing a region between residue 650 and 700 of human Forkhead box protein M1 using the numbering given in entry NP_068772.2 (Gene ID 2305).
Additional Product Information
FOXM1 belongs to a large family of Forkhead transcription factors that possesses a winged-helix DNA-binding domain called Forkhead box (FOX). It is a transcription factor critical to cell cycle progression via its role in coordinating the G2/M phase transition. FOXM1 is ubiquitously expressed in proliferating cells but is absent in differentiated cells. FOXM1 overexpression has been detected in a variety of tumor types including breast, lung, prostate, and liver cancer, and appears to be involved in tumorigenesis-associated processes such as angiogenesis and metastasis. In light of these findings, FOXM1 has recently become an attractive target for anti-cancer therapy.
Alternate Names
a novel forkhead box M1 isoform FOXM1D; FKHL16; forkhead box protein M1; Forkhead, drosophila, homolog-like 16; forkhead-related protein FKHL16; FOXM1A; FOXM1B; FOXM1C; hepatocyte nuclear factor 3 forkhead homolog 11; HFH11; HFH-11; HNF-3; HNF-3/fork-head homolog 11; INS-1; M-phase phosphoprotein 2; MPHOSPH2; MPM-2 reactive phosphoprotein 2; MPP2; MPP-2; PIG29; transcription factor Trident; TRIDENT; winged-helix factor from INS-1 cells
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (A120-101P).
Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (A120-113P) with 5% Normal Pig Serum (S100-020) added to the blocking buffer.