Rabbit anti-Rad21 Recombinant Monoclonal Antibody [BLR052F]
Product Details
Specifications
Immunogen was a peptide representing a region between residue 581 and the C-terminus (residue 631) of human Double-strand-break repair protein Rad21 homolog using the numbering given in entry NP_006256.1 (Gene ID 5885).
Additional Product Information
Rad21, also called SCC1 (sister chromatid cohesion protein 1), is part of the mitotic cohesin complex that consist of SMC1, SMC3, SCC3 and SCC1. The cohesin complex is important to sister chromatid separation and segregation during mitosis and meiosis and also plays a role in double-strand break repair by homologous recombination. Rad21 has been demonstrated to be cleaved by caspase proteins to trigger sister chromatid separation and during apoptotic signaling.
Alternate Names
CDLS4; double-strand-break repair protein rad21 homolog; hHR21; HR21; HRAD21; kleisin; MCD1; MGS; nuclear matrix protein 1; NXP1; NXP-1; protein involved in DNA double-strand break repair; RAD21 homolog; SCC1; SCC1 homolog; sister chromatid cohesion 1
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).