Rabbit anti-VHL Recombinant Monoclonal Antibody [BLR388P]
Product Details
Specifications
Immunogen was a peptide representing a region between residue 50 and 100 of human von Hippel-Landau tumor suppressor (aka VHL) using the numbering given in entry NP_000542.1 (Gene ID 7428).
Additional Product Information
VHL encodes a component of a ubiquitination complex; it is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. In addition to oxygen-related gene expression, VHL plays a role in many other cellular processes including cilia formation, cytokine signaling, regulation of senescence, and formation of the extracellular matrix. Variants of VHL are associated with von Hippel-Lindau syndrome, pheochromocytoma, erythrocytosis, renal cell carcinoma, and cerebellar hemangioblastoma. [Taken from NCBI Entrez Gene (Gene ID:7428)]
Alternate Names
elongin binding protein;HRCA1;protein G7;pVHL;RCA1;VHL1;von Hippel-Lindau disease tumor suppressor;von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (A120-101P).